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Published online April 22 2013 DOI: 10.1002/emmm.201202140 Full open access research for Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system by Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Prschel and Mark Noble in Journal of Biology

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The kynurenine pathway is the longest NAD + biosynthetic pathway: the catabolism of tryptophan through kynurenine produces quinolinic acid, which is then converted to nicotinic acid mononucleotide, an intermediate in NAD + metabolism