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To mitigate the well-established risk of DKA, patients were required to have a total daily insulin requirement of 0.5 U/kg, undergo frequent home ketone monitoring and receive structured education [28]

When researchers added cyclodextrin absorption enhancers, specifically dimethyl-beta-cyclodextrin at concentrations of just 2% w/v, nasal peptide bioavailability in animal models jumped to 70-100%

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