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The primary consideration is that women using hormonal contraceptives may require dose adjustment, as exogenous estrogen can increase IGF-1 binding proteins and alter the free IGF-1 fraction measured in standard assays

Gold et al., 2012)

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It is characterised by impairments in social communication, which manifest as problems with understanding emotions and with non-verbal communication, such as eye contact and smiling, and in failures to develop, maintain and understand social relationships