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Antifungals targeting cell wall Inhibitors of -1,3-glucan biosynthesis A membrane-integrated enzyme, UDP-glucose (1,3)-D-glucan--3-D-glucosyltransferase, referred to as -1,3-glucan synthase (EC 2.1.4.34) [152], comprises a membrane-associated catalytic subunit, Fks, and a cytosolic regulatory subunit, Rho1 [153]

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However, adverse effects included fatigue, insomnia, and small increases in fasting glucose and insulin resistance