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168,169,170,171,172,173,174,175,176,177 Additionally, PARPs and sirtuins also simulate genomic damage-signaling kinases, including ATM, p53, DNA-PK, CIRBP and FOXOs, to accelerate DNA repair

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10.1038/s41598-018-19701-7 Sci

The central player is -MSH, a peptide hormone that acts like a key, binding to a family of five distinct receptors known as melanocortin receptors (MC1R through MC5R)