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8 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 9 Study Rationale The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing in the U.S., accounting for over half of all cases of heart failure
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Clinical trials have consistently demonstrated that this restoration leads to a dramatic, measurable reduction in specific biomarkers of systemic oxidative damage, such as TBARS (thiobarbituric acid reactive substances) and F2-isoprostanes, which are direct indicators of lipid membrane destruction
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