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Among them, gastrointestinal adverse reactions mainly occurred in the early stage of the first drug use, with mild to moderate degrees (109)

Regarding additional residues of ScGrx7 that could form an interaction site for GSH, we suggest Asp144 and Glu147 in helix 3 as well as the hydroxyl group of conserved Tyr110: First, helix 3 and Tyr110 are both replaced in enzymatically inactive glutaredoxins 11,12 (Fig