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n = 12 donors

Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice

In the ATTAIN-1 trial, adverse events led to treatment discontinuation in up to 10.3 percent of patients on the drug, compared to only 2.7 percent on placebo

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