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Since there are no head-to-head trials comparing oral semaglutide for obesity to orforglipron, this indirect treatment comparison from the ORION study provides important information that can be used during the shared decision-making process. Perspective Back to Top With respect to the population-adjusted indirect treatment comparison, the findings suggest that semaglutide 25 mg tablets were associated with significantly greater mean weight loss compared with orforglipron 36 mg over a 52-week maintenance period

Once thyroid function is stable, thyroid function tests are typically performed annually, but more frequent testing is warranted during active weight loss

BPC-157 (Body Protection Compound 157) is a synthetic peptide derived from a naturally occurring protein in the human stomach