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The fact that protein cyclization is seldom used for protein optimization cannot be ascribed to inappropriate NC distances, because half of the protein domains found in the protein data bank (PDB) have their C and N extremities joinable by linkers made of a few amino acids 40

Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 No association of plasma L-Cn levels with the indicated SNPs