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Notably, the REWIND trial had the lowest proportion of randomized patients who had established cardiovascular disease at baseline (only 31%) of the 6 major trials of GLP-1 receptor agonists

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Side effects typical of GLP-1 RAs include:22 Nausea Bloating Vomiting Diarrhea Abdominal pain Belching Flatulence Most of these symptoms are associated with these drugs' ability to slow down your digestion.12 As you acclimate to your bodys changing digestive rhythm and consume fewer calories per meal, these side effects tend to dissipate