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published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling

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Fortunately, several evidence-based strategies can help manage this side effect, including dietary modifications, hydration techniques, and adjusting injection timing

Nevertheless, the usefulness of NNT is recognized by its inclusion within the Consolidated Standards of Reporting Trials (CONSORT) statement [30, 31]