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All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes

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Stepped-care beats one-size-fits-all approaches : Personalizing treatment based on early response patterns rather than fixed timelines reduces costs by 42% while achieving comparable or superior outcomes to standard behavioral interventions