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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

Once dead, animals are immediately decapitated, the temporal bones are isolated, and the middle ear bullae are opened to expose the cochleae

CPTI can crosstalk with various cellular signaling pathways involved in cancer pathogenesis

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