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The polar residues S251 and E253 in ICL2 form two hydrogen bonds with K34 GN and Q35 GN , and H8 forms hydrogen bonds with G (E402 8.53b R164 ICL1 D312 G ), but these interactions are not observed in the ligand-free GIPR structure (Supplementary Fig

Esto permite mantener la constancia sin complicaciones ni interrupciones significativas en nuestra jornada cotidiana