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HRs and their corresponding 95% confidence intervals (CIs), along with tests for proportionality, were calculated using the survival package in R version 3.2.3

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Together, these therapeutic advances underscore the emergence of cardiac proteostasis as a druggable, systems-level target

Based on these data, PEM and atypical Spitz tumor might represent melanocytic tumors of low-grade (mostly lymphotropic) malignancy different from classical melanoma: it seems thus reasonable to include atypical Spitz tumor into the melanocytoma rubric, as suggested since the beginning (49)