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Response: We continue to believe that decreasing the maximum amount of time an ACO can participate in one-sided risk under the BASIC track from 7 to 5 years will promote direct accountability for health outcomes and the costs of beneficiary care, while improving the quality of care for Medicare beneficiaries

Growth factor receptor-bound protein 2 (GRB2), an adaptor protein, binds to the receptor and recruits Son of Sevenless (SOS), a guanine nucleotide exchange factor (GEF)