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This eosinophilia, in both the lung and BALF, was discernibly lower in mice treated with melatonin alongside AA-exposure ( Figures 1G, H )

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Alternatively, the increased longevity could have resulted from decreased product-inhibition of the nematode homolog of cytoplasmic GPD1 by decreasing glycerol-3-phosphate levels, leading to increased flux through GPD1 to oxidize the cytoplasmic [NAD + ]/[NADH], a known prolongevity intervention (Lautrup et al., 2024)