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Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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That is, the p Ka of GSSH is 6.9, which is two orders of magnitude lower than that of GSH, which is 8.9 ( Ka implies that supersulfides have a greater tendency to deprotonate and form anionic species under physiological conditions, thereby increasing their reactivity with electrophilic molecules