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doi: 10.1038/s41590-023-01491-4 98 TewaltEFCohenJNRouhaniSJGuidiCJQiaoHFahlSPet al

Some individuals may increase more slowly, pause dose increases, or remain at a lower effective dose

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These effects may lead to lower fluid intake or increased fluid loss, resulting in mild dehydration. Even mild dehydration can affect bladder comfort and may increase the risk of urinary irritation, as reduced urine output means the urinary tract is flushed less frequently