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J Med Chem 58(18):73707380 Agerso H et al (2002) The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men

88,89 Under energy-deprived conditions, such as fasting, SIRT1 activity is upregulated, promoting fatty acid oxidation and ketogenesis via the PGC-1/PPAR axis, thereby improving hepatic metabolic adaptability

Third, controlled release offers the possibility of localized drug delivery by placement of a delivery device or formulation at the site of disease