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Thus, selectively removing senescent cells in chondrocytes is crucial to assure the quality of cells for ACI

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Moreover, these foods have a high content of additives (emulsifiers, colorings, sweeteners, preservatives) and other industrial ingredients (such as hydrolyzed proteins, hydrogenated or de-esterified oils), used to make the final product more palatable [185]

When considering the potential metabolic pathways that lead to hyperhomocysteinemia it is important to note that the amino acid methionine, but not the amino acid cysteine, is the dietary precursor of homocysteine (Stipanuk et al, cited in Xiao et al, 2013)