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Retatrutide with resistance training produces the best body composition outcomes of any weight loss method, including approaches that produce less total weight loss

According to Leerink analyst David Reisinger, retatrutide showed higher gastrointestinal side effects than Zepbound, as expected, plus much higher rates of dysesthesia. William Blairs Andy Shea acknowledged that the placebo-adjusted weight loss compares favourably to the 18% figure for Zepbound but predicted the drug will likely be limited to individuals at the higher end of the BMI spectrum. In plain terms: retatrutide works spectacularly, but its probably too punishing for routine use

While most clinical focus has centered on weight loss, preliminary research indicates that these medications may influence the same neural circuits that drive compulsive drinking behaviors