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To evaluate the otoprotective efficacy of the compounds, cochlear samples are immunostained with a combination of markers specific for hair cells (Myosin V1, Myosin VIIA, Parvalbumin, etc.), SGNs (TUJ1, Neurofilament, etc.), f-actin, cell death, cell stress, etc

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When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase

The specificity of AOD 9604 for fat metabolism has generated interest in its potential role in weight loss and body composition improvements while minimizing the side effects typically seen with full-scale hGH treatments