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In conclusion, treatment with once-weekly subcutaneous semaglutide in conjunction with behavioral intervention in adults with overweight (with at least one weight-related comorbidity) or obesity (without diabetes) was associated with clinically impactful and sustained weight loss of 15.2% at week 104, along with improvements in weight-related cardiometabolic risk factors

The adjusted mean change in diastolic blood pressure (DBP) in the semaglutide group was 1.6 mm Hg (s.e

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Findings from one year after participants stopped taking semaglutide include 18% of study participants regained 100% or more of their lost weight