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Losing muscle slows your metabolism, weakens your body, and sets the stage for rapid fat regain if and when you stop the medication

Tangent GLP-1 drugs have been studied for their ability to maintain muscle mass while also helping patients lose weight

This process doesnt suddenly appear later in life

Published Phase 2 effect sizes most prominently the ~24 percent mean body weight reduction at the 12 mg dose tier in the obesity Phase 2 (PMID 37366315) exceed those reported for dual or single agonists at comparable durations, an outcome that researchers attribute to the additional glucagon-arm contribution to body-composition and energy-expenditure pathways