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Addresses a central hallmark of aging: mitochondrial dysfunction is not peripheral to aging it is mechanistically central to it Systemic ROS reduction: reducing oxidative stress at its source provides cellular protection across all tissues simultaneously Cellular energy preservation: maintaining energy production capacity as cells age supports all other cellular functions Brain & Cognitive Support The brain is the most energy-intensive organ in the body consuming approximately 20% of the bodys total energy output despite comprising only 2% of its mass

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5 Conclusion Our study highlights a substantial association between DPP-4 inhibitors, notably sitagliptin, and biliary disorders