Equally important, there are also some natural active ingredients, for instance, geniposide extracted from gardenia flowers, which has demonstrated the effect of inhibiting ferroptosis in other diseases (94), and at the same time can regulate osteoblast apoptosis through the Nrf2/ NF-kB pathway, preventing and treating osteoporosis
the two conditions share common pathogenic mechanisms and influence each other Excessive glutamate release and activation of glutamate receptors promotes glioma growth, cell death and epileptic activity GABAergic signalling is antiproliferative, whereas chloride accumulation is required for mitosis and migration of tumour cells, and is responsible for epileptogenic depolarizing GABAergic activity in neurons The molecular target of rapamycin (mTOR) signalling pathway and epigenetic abnormalities are also involved in epileptogenesis and tumour growth As a result of the shared pathogenic mechanisms, antiepileptic drugs can have antitumour effects, and antitumour therapy can control seizures Single drug therapies targeting the shared mechanisms are now being assessed for combined seizure and tumour control, and have the advantage of lower risks of adverse effects and drug interactions Abstract Epilepsy often develops in patients with glioma, and the two conditions share common pathogenic mechanisms
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