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Activation of the canonical pathway is initiated by the binding of Wnt ligands to the Frizzled (FZD) receptor and the low-density lipoprotein receptor-related protein (LRP) 5/6 co-receptor complex, thereby triggering intracellular signal transduction [145]

Erianin affects the expression of cancer-associated genes by regulating pyruvate carboxylase (PC)-mediated Wnt/-catenin signaling pathway, while promoting mitochondrial oxidative stress and inhibiting glycolysis and the proliferation of liver cancer cells (20)

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3.2 Therapeutic potential in obesity Although the incretin effects of GIPR undoubtedly play a crucial role in preventing postprandial glucose excursion, there is still intensive debate on whether the GIPR should be activated or inhibited for the treatment of obesity