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Injection of a virus expressing ME1 into the vestibular nucleus of the brain induced a 2-fold induction of ME1 levels that led to improved locomotion and decreased neuroinflammation in a mitochondrial electron transport chain (ETC) complex I subunit (NDUFS4)-deficient mouse model of Leigh syndrome, consistent with neuroprotection, although survival was not affected (Del Prado et al., 2024)

Xu, S., Pan, J., Cheng, X., Zheng, J., Wang, X., Guan, H

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In fact, researchers have found that certain drugs promote a bacterial environment within the gut that despite not being classified as pathogenic, can still promote arthritic symptoms in autoimmune diseases (3)