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97 Accumulating evidence indicates that autophagic activity decreases with age in multiple organisms and that the material transport of lysosomes decreases, indicating that damaged autophagy is a canonical characteristic of aging in organisms

Discussion At present, the proportion of the elderly population in the world is growing rapidly, and the challenges associated with aging have become an international problem

Now I would be interested if this effect is dose dependent and would exhibit the same positive impact in healthy BMI-range persons with substance-abuse disorders, who do not need to lose weight