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For protocols that value regulatory-grade depth above all, tirzepatide remains the standard

Below a graph showing mean BMI change over time by baseline BMI category in SURMOUNT-1 through SURMOUNT-4 is positioned along a well-known graph from the SURMOUNT-4 study showing weigh regain in placebo arm after open-label lead-in period, and not less known graph from STEP-1 study with weight regain dynamic in off-treatment extension period

There was an overall weight gain in these patients and a decrease in the frequency of clinical signs such as vomiting and diarrhea

The biggest difference is between topical serums and injectable GHK-Cu