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The role of IGF-1 signaling in prostate development and normal prostate physiology has not been established in vivo , however, silencing IGF-1 in not only the WPMY-1 prostate stroma cell line, and but also BPH-1, a prostate epithelium cell line, decreased cell proliferation and increased apoptosis rate in vitro (33)

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Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro