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Most available data are derived from in vitro or animal models, which may not fully replicate human physiological responses
Idh1 was located in the mitochondrial matrix and converted isocitrate to -ketoglutarate (-KG) and NADP to NADPH
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Microarray studies using Affymetrix gene chips have demonstrated GHK-Cu resetting aging-related gene expression profiles in dermal fibroblasts, including upregulation of genes encoding superoxide dismutase (SOD1), metallothionein, collagen types I and III, and multiple anti-inflammatory interleukins
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