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2 3 The proposed mechanisms include promotion of angiogenesis (new blood-vessel formation), effects on the nitric-oxide system, and stimulation of fibroblast outgrowth and cell migration through signaling pathways such as FAK-paxillin

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However, in a previous study carried out in Calu-3 cells, it was shown that exposure to cigarette smoke causes a decrease in the synthesis of CFTR mRNA, which was reflected in the expression of the protein [121]