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The most important of these are TGF- family ligands and lysophosphatidic acid, which activate SMAD transcription factors and serum response factors (SRF), respectively, to promote the activation of tumor-associated fibroblasts [29, 30]

People suffering from chronic pain may feel depressed, angry and frustrated about their condition

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

Simultaneously, it increased the activities of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR) and ascorbate peroxidase (APX)