Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric ( S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes) 16,22,23
Basically, every time that the pleasure system is kicked in in high gear, an absolutely spectacular event, you cannot be more ecstatic, there is a mirror symmetric activation of the pain system
A potential alternative to weekly SubQ shots is daily oral Rx with orforglipron, a small molecule GLP-1 agonist with good bioavailability via the oral route in contrast to oral semaglutide (Rybelsus) which has food and timing restrictions
MMWR Morb Mortal Wkly Rep 66(15):397403 De Filippo C et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa