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Regular follow-ups are necessary to monitor weight loss progress, adjust dosages as needed, manage side effects, and catch any early warning signs of complications such as gallbladder issues or pancreatitis

In addition, data obtained in preclinical models and small cohorts suggest that the GLP1RAs liraglutide may downregulate PCSK9, a major inhibitor of LDL-receptor expression associated with the development of atherosclerosis [25, 26]

(iv) increased accumulation or production of potentially toxic saturated very long chain fatty acids 153,157 (Fig

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