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The GLP-1RAs have been shown to reduce food intake, promote weight loss, and improve metabolic function in both animals and humans

Pregnant women with rosacea are advised to use topical treatment and antimicrobial drugs like azithromycin, erythromycin, or clarithromycin, which are safe during pregnancy

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Less body weight means less compressive load on the knee with every step Adipose tissue produces inflammatory signalling molecules (IL-6 and TNF-alpha) that drive joint pain, and reducing fat tissue reduces those signals 3 The IDEA trial in 2013 demonstrated clinically meaningful reductions in pain through diet and exercise alone, without any GLP-1 medication 3 Whether semaglutide also has anti-inflammatory effects independent of weight loss, through GLP-1 receptors on immune cells, is a separate question