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In pulmonary vein cardiomyocytes (Chan et al., 2023), GLP-1 amide modulates ionic currents by decreasing L-VGCC and Na + /Ca 2+ exchanger current while increasing sarcoplasmic reticulum Ca 2+ content

Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification

Dispose of the needle and syringe: Carefully remove the needle from the injection site and dispose of the used needle and syringe in a puncture-resistant container

Use the minimum effective dose and increase only if needed