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Researchers administering cisplatin (5 mg/kg) to rats found marked toxic effects related to the dosage and timing in relation to their sexual cycle ( 4 Effective strategies to prevent the POF induced by cisplatin Due to the significant renal toxicity of cisplatin therapy, pre-treatment hydration therapy must be initiated before the treatment ( For gastrointestinal toxicity causing nausea and vomiting, antiemesis drugs can be used before the medication, a four-drug combination regimen consisting of NK1 receptor antagonist, 5-HT3 receptor antagonist, dexamethasone, and olanzapine has been recommended by the American Society of Clinical Oncology guidelines ( For hematological toxicity, granulocyte colony stimulating factor (G-CSF), recombinant human platelet growth factor, erythropoietin (EPO) and other drugs can be used to treat the symptoms, the chemotherapy doses can be adjusted, or blood transfusions may be required ( The neurotoxicity caused by cisplatin treatment cannot be avoided

Rousta et al., 2022)