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Key findings from clinical trials include: Reductions in waist circumference, an indirect marker of abdominal fat Improvements in metabolic markers associated with visceral adiposity (HbA1c, lipid profiles, liver enzymes) Decreased hepatic fat content in patients with fatty liver disease It is important to understand that GLP-1 medications do not 'burn' fat through thermogenesis or direct lipolysis

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Subjects from both studies on VYVANSE had a statistically significantly greater reduction from baseline in mean number of binge days per week at Week 12

Methods: Among 102 patients who were enrolled in the Japanese phase 3 clinical trial of sofosbuvir and velpatasvir (SOF/VEL) with or without ribavirin (RBV) treatment to decompensated cirrhotic patients with HCV, 99 patients who agreed to a long-term follow up study were included in this study