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Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with difficult-to-treat nail and scalp psoriasis: results of 2 phase III randomized, controlled trials (ESTEEM 1 and ESTEEM 2) J Am Acad Dermatol

Key Mechanisms of Action: Increased Collagen Synthesis: Stimulates fibroblasts in the skin to produce collagen, reducing wrinkles

Types of minimally invasive surgery for spinal stenosis include: Non-fusion implants are surgically implanted devices that preserve spinal motion while alleviating nerve compression

Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication