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Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55

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[4] Given that Trulicity slows gastric emptying, this effect may be additive in patients whose gastric motility is already altered post-surgery, and this should be considered when assessing suitability