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Earlier this year, an FDA advisory committee recommended that two other DPP-4 inhibitors AstraZeneca's (AZ) Onglyza (saxagliptin) and Takeda's Nesina (alogliptin) should have their labels amended to indicate a possible increased risk of hospitalisation due to heart failure

Here, PNS1 was crystallized by mixing protein and reservoir (0.3 M sodium formate, 0.1 M sodium citrate buffer, pH 5.0, 15% PEG 3350, 0.71.5% 1-butanol) in a 1:1 or 1:1.5 ratio in sitting or hanging-drop plates

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