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He measured blood glucose levels continuously for 24 hours and found that a single injection of exendin-4 produced sustained glucose lowering throughout the entire day

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Moreover, 6 week exposure to CUMS showed further GABA level reductions in tissues such as hippocampus, blood and feces, suggesting that more widespread neurotransmitter depletion may be stress type and duration dependant (Jia et al., 2024)

GLP-1R agonists were initially used to treat T2DM and soon after it was found that these drugs possess many other physiological properties, such as neuroprotection, neurotrophic, and anti-inflammatory effects, which may be useful to slow the progression of AD ( Figure 3 ) ( Figure 3 Anti-inflammatory effects Previous studies have shown that GLP-1R mimics have anti-inflammatory effects in the CNS (139141)