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Possible Direct Mechanisms Although indirect effects dominate, GLP-1 receptors are expressed in reproductive tissues, suggesting potential direct roles: Ovarian Effects: Animal studies demonstrate GLP-1 receptor activation can influence granulosa cell function, increase cyclic adenosine monophosphate (cAMP), and modulate steroidogenesis

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Jansman 2001)

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PC j is the variance contribution rate corresponding to the j-th principal component (cumulative contribution rate 85%)

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Rising investments in diabetes care programs and chronic disease management initiatives further support sustained growth in the U.S

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