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Weight management presents a particular challenge, as many women with PCOS experience difficulty losing weight due to metabolic abnormalities

[50] However, it is important to note that fenfluramine, rimonabant and lorcaserin used very different molecular mechanisms (acting mainly on serotonin 2c receptors [51] in the hypothalamus [52] or CB1 receptors [53] ) from GLP1R, GIPR or GR agonists and likewise do not imply anything on the possible dangers of GLP1R, GIPR or GR agonists

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Individuals with a personal or strong family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, or active pancreatitis should not take these medications