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In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, and inhibits the apoptosis pathway

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Notably, patients with variants in the linker, MTS, or P domains exhibited later onset, milder epilepsy severity, and better responsiveness to antiepileptic drugs, suggesting that the functional domain distribution of LONP1 variants may influence the severity grading of epileptic phenotypes [89]