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Caraballo C, Herrin J, Mahajan S, Massey D, Lu Y, Ndumele CD, Drye EE, Krumholz HM

Biol Rev Camb Philos Soc 91:452468

Individuals on Tirzepatide (n = 50) reported a median dose of 7.5 mg [range 0.515 mg], and on Semaglutide variants: Ozempic or Wegovy (n = 54) reported a median dose of 1 [range 0.252.4] and Rybelsus (n = 2) reported doses of 7 mg and 14 mg

Additional categories being evaluated include apolipoprotein E \(\varepsilon\) 4 ( APOE4 ) effects, lipids and lipoprotein receptors, neurogenesis, oxidative stress, bioenergetics and metabolism, vascular factors, cell death, growth factors and hormones, circadian rhythm, and epigenetic regulators